Scientific Background

Related projects:

MONARCA - MOnitoring, treAtment and pRediCtion of bipolAr Disorder Episodes

PSYCHE - Personalised monitoring SYstems for Care in mental HEalth

Related cure approaches:

Province of Trento:

Region H:

Related pubblications:

1) World Health Organization (2011), “mHealth. New horizons for health through mobile technologies”, Global Observatory for eHealth series -

2) Monitoring Editor: Gunther Eysenbach, Reviewed by Zaher Hajar and Robyn Whittaker, Maddalena Fiordelli, Nicola Diviani, and Peter J Schulz (2013), “Mapping mHealth Research: A Decade of Evolution”, Journal of Medical Internet Research, May 2013, 15(5): e95 -

3) GSMA, mHealth and the EU regulatory framework for medical devices -

4) Medical devices European Commission Regulatory framework -

5)  Faurholt-Jepsen MVinberg MChristensen EMFrost MBardram J, Kessing LVDaily electronic self-monitoring of subjective and objective symptoms in bipolar disorder--the MONARCA trial protocol (MONitoring, treAtment and pRediCtion of bipolAr disorder episodes): a randomised controlled single-blind trialBMJ Open. 2013 Jul 24;3(7). pii: e003353. doi: 10.1136/bmjopen-2013-003353. Print 2013.

6) Faurholt-Jepsen MFrost MVinberg M, Christensen EMBardram JEKessing LVSmartphone data as objective measures of bipolar disorder symptoms. Psychiatry Res. 2014 Mar 13. pii: S0165-1781(14)00187-5. doi: 10.1016/j.psychres.2014.03.009. [Epub ahead of print]

7) Bardram, Jakob E., Mads Frost, Károly Szánto, Maria Faurholt-Jepsen, Maj Vinberg, and Lars Vedel Kessing. “Designing Mobile Health Technology for Bipolar Disorder: A Field Trial of the Monarca System.” In In Proceedings of the SIGCHI Conference on Human Factors in Computing Systems, New York, NY, USA, 2013, pages 2627–2636.

8) Frost, Mads, A Doryab, Maria Faurholt-Jepsen, Lars Vedel Kessing, and Jakob E. Bardram.“Supporting Disease Insight through Data Analysis: Refinements of the Monarca Self-Assessment System.” InSupporting Disease Insight through Data Analysis: Refinements of the Monarca Self-Assessment System, ACM, 2013.

9) Agnes Grunerbl, Venet Osmani, Gernot Bahle, Jose C. Carrasco, Stefan Oehler, Oscar Mayora, Christian Haring, Paul Lukowicz "Using smart phone mobility traces for the diagnosis of depressive and manic episodes in bipolar patients" ACM proceedings of 5th Augmented Human International Conference, DOI:10.1145/2582051.2582089, Kobe, Japan, March 2014

10) Mayora, Oscar; Arnrich, Bert; Bardram, Jakob; Dräger, Carsten; Finke, Andrea; Frost, Mads; Giordano, Silvia; Gravenhorst, Franz; Grunerbl, Agnes; Haring, Christian; Haux, Reinhold; Lukowicz, Paul; Muaremi, Amir; Mudda, Steven; Ohler, Stefan; Puiatti, Alessandro; Reichwaldt, Nina; Scharnweber, Corinna; Troester, Gerhard; Kessing, Lars Vedel; Wurzer, Gabriel, Personal health systems for bipolar disorder: anecdotes, challenges and lessons learnt from MONARCA project.  Pervasive Computing Technologies for Healthcare 7. IEEE Press, 2013. p. 424-429.

11) Faurholt-Jepsen M, Vinberg M, Frost M, Christensen EM, Bardram JE, Kessing LV (2014). Daily electronic monitoring of subjective and objective measures of illness activity using smartphones in bipolar disorder- The MONARCA II trial protocol: A randomized controlled single-blind parallel-group trial. BMC Psychiatry, 25;14(1):309

12) Faurholt-Jepsen M, Brage S, Vinberg M, Christensen EM, Knorr U, Kessing LV (2015) Electronic monitoring of psychomotor activity as a supplementary objective measure of depression severity. Nordic Journal Psychiatry, Feb;69(2):118-25.

13) Faurholt-Jepsen M, Frost M, Ritz C, Christensen EM, Jacoby AS, Mikkelsen RL, Knorr U, Bardram J, Vinberg M, Kessing LV (2015) Daily electronic self-monitoring in Bipolar Disorder using smartphones- The MONARCA I trial: A randomized, placebo-controlled, single-blind, parallel group trial. Psychological Medicine, 2015 Jul 29:1-14

14) Faurholt-Jepsen M, Ritz C, Frost M, Mikkelsen RL, Christensen EM, Bardram J, Vinberg V, Kessing LV. (2015) Mood instability in bipolar disorder type I versus type II -  Continuous daily electronic self-monitoring of illness activity using smartphones. Journal of Affective Disorders 2015 Nov 1;186:342-9

15) Faurholt-Jepsen M, Ritz C, Frost M, Mikkelsen RL, Christensen EM, Bardram J, Vinberg V, Kessing LV. (2015) Smartphone data as an electronic biomarker of illness activity in bipolar disorder. Bipolar Disorder, 2015 Sep 23. doi: 10.1111/bdi.12332